Highlights
  • Outcome of Ceregene's Phase-2 Trial CERE-120, Todd Sherer, interview of Raymond Bartus, PhD, 1/29/2009, Michael J. Fox Foundation: This frank discussion of the "profound placebo effect" (PPE) and its intrusion into the gold-standard double-blind clinical trial opens the door to re-considering the PPE as an "endogenous brain-repair mechanism" due to the organ function of the brain itself -- that of consciousness -- as a self-organizing, dynamic process known for centuries as 'healing' and being re-discovered as "cognitive therapy" in rehabilitation medicine. Further, this effect was noted in the literature of sociology following productivity tests conducted by MIT at the Hawthorne, MA plant of Western Electric Company, in 1924.
    See in connection with what Dr. Bartus calls "The Profound Placebo Effect" the following: "Placebo mechanisms and reward circuitry: clues from Parkinson's disease" dela Fuente-Fernández R, Schulzer M, Stoessl AJ. Biol Psychiatry. 2004 Jul 15;56(2):67-71. Also:
    "Placebo and Nocebo Effects Are Defined by Opposite Opioid and Dopaminergic Responses" David J. Scott, BS; Christian S. Stohler, DDS, PhD; Christine M. Egnatuk, BS; Heng Wang, PhD; Robert A. Koeppe, PhD; Jon-Kar Zubieta, MD, PhD Arch Gen Psychiatry. 2008;65(2):220-231. Important CONCLUSIONS for disease therapeutics:
    "We have herein demonstrated that placebo [pleasure] and nocebo [pain] effects engage specific neurotransmitter systems as a consequence of cognitive-emotional assessments of their efficacy. Dopaminergic and opioid systems modulate a number of processes, including the regulation of reward and affective states, cardiovascular, immunological, and neuroendocrine functions, as well as the effects of substances of abuse and the development of drug dependence. This line of inquiry offers the possibility that nonpharmacological interventions exploiting these systems may affect the capacity of the organism to adapt to allostatic challenges, modifying risk for various illnesses or their progression."

  • "Nanomedicine Targets Cancer: Viewing each human body as a system of interacting molecular networks and targeting disruptions in the system with nanoscale technologies can transform how disease is understoood," Heath, James R., Davis, Mark E. and Hood, Leroy, Scientific American, vol. 300, no. 2, February 2009, pp. 44—51. [specific ref. to PD and "MS, AD and prion disease models"]
    This article offers the Western therapeutic approach of Systems Medicine, which we find converging with that of Eastern Medicine, specifically Acupuncture.

    Brain Wellness Innovators is investigating the science of the neuron from the physics of light and energy. Where protein chains break is where energy is disrupted and transmission or transport lost. The Second Law of Thermodynamics assumes systems are in equilibrium, which applies to the grand scale but there is the self-organizing counter-current of nature. We hypothesize that the complexity of self-organization manifests a new qualitative level at human consciousness. Our method is to use teachings in Tibetan Yoga to discipline the mind to step aside and experience creativity in the immediacy of the present. This "Be here now" discipline maximizes the physiological effect of bringing the nervous system into phase with harmonious consciousness.

  • "Does Nature Break the Second Law of Thermodynamics? In seeming defiance of the second law of thermodynamics, nature is filled with examples of order emerging from chaos. A new theoretical framework resolves the apparent paradox" by J. Miguel Rubí, Scientific American, November 2008.

Contact Info
an image
Brain Wellness Innovators, LLC

Sarasota, FL
Phone: (941) 952-9902

We translate the latest research into innovative therapy to help the brain heal itself.

Why does their tremor seem to subside when people with Parkinson's Disease (PD) are engaged in creative work?

RELEVANCE:
Brain Wellness Innovators is investigating an effective method for cognitive rehabilitation therapy that improves the underlying health of the PD patient and slows or stops the present steady progression of this intractable disease. We consider PD the best candidate for this approach because current research is in a transition phase since the results of the Phase-II Cere-120 (neurturin) trial; even though stem-cell surgery research has the go-ahead, some researchers question the premise that the disease begins with loss of substantia-nigral dopamine production capability. Due to what we call the "Parkinson Noumenon" (PN) -- the diminution of symptoms during skilled motor activity -- we believe the PD patient can be engaged in active collaboration, as are physical rehabilitation patients after injury or stroke.

INNOVATION:
The three therapeutic modes of this protocol use a systems-medicine approach to treat the non-linear, complex disruption of protein-messenger systems (and of their axonal transport) in the brain. The protocol systematically uses the "Profound Placebo Effect" (PPE) named by Dr. Raymond Bartus after the Cere-120 Phase-2 results, to develop a synergy of therapies for cognitive rehabilitation that the researchers believe can identify the PPE as a specific "endogenous brain repair mechanism" or EBRM.

This is a clinical trial to determine the synergistic effect of Acupuncture, Neurofeedback, and Mindfulness-based Art Therapy (MBAT), defined specifically as an investigation of the PN during skilled activity, such as, creativity, music, and eastern energy-exercise, in order to train patients to access this brain state at will, particularly to counteract rigidity and dyskinesia.

APPROACH:
Acupuncture targets the alternate motor pathway selected for this investigation, brings the CNS and PNS into phase, and restores the immune system. By recording, identifying, and mapping brain frequencies of individual patients when in the target state, the researchers are preparing a synthesis of this protocol with computational neuroscience to find strange attractors in two related chaotic systems, the Parkinson patient's brain and heart arhythmia, then using neurofeedback to train the patient to "re-cognize" or induce optimal rhythm or frequency by synchronized breathing.

SIGNIFICANCE:
Current research in PD indicates frustration with dopamine replacement techniques and the new approaches of nanotechnology or optogenetics are too distant to help PD patients now.

With corroborative data for the efficacy of the treatment synergy, Brain Wellness Innovators plans to develop training and materials for practitioners in the three therapeutics, as well as software animated to optimal frequency patterns identified in our research for patients' collaboration in their own healthcare. As the phases of investigation progress, the researchers plan to expand the protocol to identify patterns and develop treatment for other brain disease, as well as for traumatic injury.